USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: PRDX1_HUMAN USC-OGP 2-DE database:  PRDX1_HUMAN PRDX1_HUMAN General information about the entry View entry in simple text format Entry name PRDX1_HUMAN Primary accession number Q06830 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Peroxiredoxin-1; EC=1.11.1.15; AltName: Full=Natural killer cell-enhancing factor A; Short=NKEF-A; AltName: Full=Proliferation-associated gene protein; Short=PAG; AltName: Full=Thioredoxin peroxidase 2; AltName: Full=Thioredoxin-dependent peroxide reductase 2;. Gene name Name=PRDX1 Synonyms=PAGA, PAGB, TDPX2 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_6-11 {PLATELET 6-11} Homo sapiens (Human)   map experimental info   PLATELET_6-11 MAP LOCATIONS: SPOT OGP-1031: pI=8.04; Mw=22601 Cross-references UniProtKB/Swiss-Prot Q06830; PRDX1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PRDX1_HUMAN Primary accession number Q06830 Secondary accession number(s) B5BU26 D3DPZ8 P35703 Q2V576 Q5T154 Q5T155 Sequence was last modified on  June 1, 1994 (version 1) Annotations were last modified on  March 15, 2017 (version 192) Name and origin of the protein Description RecName: Full=Peroxiredoxin-1; EC=1.11.1.15; AltName: Full=Natural killer cell-enhancing factor A; Short=NKEF-A; AltName: Full=Proliferation-associated gene protein; Short=PAG; AltName: Full=Thioredoxin peroxidase 2; AltName: Full=Thioredoxin-dependent peroxide reductase 2; Gene name Name=PRDX1 Synonyms=PAGA, PAGB, TDPX2 Encoded on Name=PRDX1; Synonyms=PAGA, PAGB, TDPX2 Keywords 3D-structure; Acetylation; Antioxidant; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; Isopeptide bond; Oxidoreductase; Peroxidase; Phosphoprotein; Polymorphism; Redox-active center; Reference proteome; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X67951; CAA48137.1; -; mRNA EMBL L19184; AAA50464.1; -; mRNA EMBL BT019740; AAV38545.1; -; mRNA EMBL CR407652; CAG28580.1; -; mRNA EMBL DQ297142; ABB84465.1; -; Genomic_DNA EMBL AB451262; BAG70076.1; -; mRNA EMBL AB451388; BAG70202.1; -; mRNA EMBL AL451136; CAI13095.1; -; Genomic_DNA EMBL AL451136; CAI13096.1; -; Genomic_DNA EMBL AL451136; CAI13097.1; ALT_SEQ; Genomic_DNA EMBL CH471059; EAX06975.1; -; Genomic_DNA EMBL CH471059; EAX06976.1; -; Genomic_DNA EMBL CH471059; EAX06978.1; -; Genomic_DNA EMBL CH471059; EAX06979.1; -; Genomic_DNA EMBL CH471059; EAX06980.1; -; Genomic_DNA EMBL CH471059; EAX06981.1; -; Genomic_DNA EMBL CH471059; EAX06982.1; -; Genomic_DNA EMBL BC007063; AAH07063.1; -; mRNA EMBL BC021683; AAH21683.1; -; mRNA CCDS CCDS522.1; -; . PIR A46711; A46711; . RefSeq NP_001189360.1; NM_001202431.1; . RefSeq NP_002565.1; NM_002574.3; . RefSeq NP_859047.1; NM_181696.2; . RefSeq NP_859048.1; NM_181697.2; . UniGene Hs.180909; -; . UniGene Hs.731900; -; . PDB 2RII; X-ray; 2.60 A; A/B=1-199 PDB 3HY2; X-ray; 2.10 A; A/B=1-199 PDB 4XCS; X-ray; 2.10 A; A/B/C/D/E/F=1-199 PDBsum 2RII; -; . PDBsum 3HY2; -; . PDBsum 4XCS; -; . ProteinModelPortal Q06830; -; . SMR Q06830; -; . BioGrid 111089; 131; . DIP DIP-33152N; -; . IntAct Q06830; 61; . MINT MINT-4999060; -; . STRING 9606.ENSP00000262746; -; . ChEMBL CHEMBL5315; -; . PeroxiBase 4501; Hs2CysPrx01; . iPTMnet Q06830; -; . PhosphoSitePlus Q06830; -; . SwissPalm Q06830; -; . BioMuta PRDX1; -; . DMDM 548453; -; . DOSAC-COBS-2DPAGE Q06830; -; . OGP Q06830; -; . SWISS-2DPAGE Q06830; -; . UCD-2DPAGE Q06830; -; . EPD Q06830; -; . MaxQB Q06830; -; . PaxDb Q06830; -; . PeptideAtlas Q06830; -; . PRIDE Q06830; -; . TopDownProteomics Q06830; -; . DNASU 5052; -; . Ensembl ENST00000262746; ENSP00000262746; ENSG00000117450; . Ensembl ENST00000319248; ENSP00000361152; ENSG00000117450; . GeneID 5052; -; . KEGG hsa:5052; -; . UCSC uc001coa.4; human; . CTD 5052; -; . DisGeNET 5052; -; . GeneCards PRDX1; -; . HGNC HGNC:9352; PRDX1; . HPA CAB004682; -; . HPA HPA007730; -; . MIM 176763; gene; . neXtProt NX_Q06830; -; . OpenTargets ENSG00000117450; -; . PharmGKB PA33722; -; . eggNOG KOG0852; Eukaryota; . eggNOG COG0450; LUCA; . GeneTree ENSGT00390000004653; -; . HOVERGEN HBG000286; -; . InParanoid Q06830; -; . KO K13279; -; . OMA TAEVHFA; -; . OrthoDB EOG091G0IE5; -; . PhylomeDB Q06830; -; . TreeFam TF105181; -; . BRENDA 1.11.1.15; 2681; . Reactome R-HSA-3299685; Detoxification of Reactive Oxygen Species; . Reactome R-HSA-5628897; TP53 Regulates Metabolic Genes; . Reactome R-HSA-8862803; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; . SIGNOR Q06830; -; . ChiTaRS PRDX1; human; . EvolutionaryTrace Q06830; -; . GeneWiki Peroxiredoxin_1; -; . GenomeRNAi 5052; -; . PRO PR:Q06830; -; . Proteomes UP000005640; Chromosome 1; . Bgee ENSG00000117450; -; . CleanEx HS_PRDX1; -; . ExpressionAtlas Q06830; baseline and differential; . Genevisible Q06830; HS; . GO GO:0005737; C:cytoplasm; IDA:MGI; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0031012; C:extracellular matrix; IDA:BHF-UCL; . GO GO:0005615; C:extracellular space; IDA:UniProtKB; . GO GO:0042470; C:melanosome; IEA:UniProtKB-SubCell; . GO GO:0005739; C:mitochondrion; IEA:Ensembl; . GO GO:0043209; C:myelin sheath; IEA:Ensembl; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0045296; F:cadherin binding; IDA:BHF-UCL; . GO GO:0004601; F:peroxidase activity; IDA:MGI; . GO GO:0003723; F:RNA binding; IDA:UniProtKB; . GO GO:0008379; F:thioredoxin peroxidase activity; IDA:BHF-UCL; . GO GO:0008283; P:cell proliferation; TAS:ProtInc; . GO GO:0045454; P:cell redox homeostasis; IEA:InterPro; . GO GO:0034101; P:erythrocyte homeostasis; IEA:Ensembl; . GO GO:0042744; P:hydrogen peroxide catabolic process; IDA:BHF-UCL; . GO GO:0042267; P:natural killer cell mediated cytotoxicity; IEA:Ensembl; . GO GO:0042345; P:regulation of NF-kappaB import into nucleus; IEA:Ensembl; . GO GO:0032872; P:regulation of stress-activated MAPK cascade; IEA:Ensembl; . GO GO:0019430; P:removal of superoxide radicals; IEA:Ensembl; . GO GO:0000302; P:response to reactive oxygen species; TAS:Reactome; . GO GO:0001895; P:retina homeostasis; IEP:UniProtKB; . GO GO:0001501; P:skeletal system development; TAS:ProtInc; . Gene3D 3.40.30.10; -; 1; . InterPro IPR000866; AhpC/TSA; . InterPro IPR024706; Peroxiredoxin_AhpC-typ; . InterPro IPR019479; Peroxiredoxin_C; . InterPro IPR012336; Thioredoxin-like_fold; . InterPro IPR013766; Thioredoxin_domain; . Pfam PF10417; 1-cysPrx_C; 1; . Pfam PF00578; AhpC-TSA; 1; . PIRSF PIRSF000239; AHPC; 1; . SUPFAM SSF52833; SSF52833; 1; . PROSITE PS51352; THIOREDOXIN_2; 1; .

Gateways to other related servers

• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
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• World-2DPAGE Portal - A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
• ExPASy - The resources web server of the Swiss Institute of Bioinformatics

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